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Dr. Stanislav Beyl

Head of Data Analysis & Reporting

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Dr. Stanislav Beyl

Dr. Stanislav Beyl leads data analysis and scientific reporting at ChanPharm. He is responsible for processing and interpreting electrophysiology datasets, developing analytical pipelines, and delivering clear, publication-ready reports to clients.

More than 20 years of research on ion channels and in the field of drug discovery. Dr. Beyl's work focused on structure-function analyses (2005–2023) and the modulation of ion channels by drugs. Of particular note are his contributions to analysis of channel gating in terms of state models (Beyl et al. 2014) and the clarification of the roles of individual S4 segments in calcium channels (Beyl et al. 2016).

Education & Career

Selected Publications

  1. 1.
    Hohaus A, Beyl S, Kudrnac M, Berjukow S, Timin EN, Marksteiner R, Maw MA, Hering S. Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder.
    J Biol Chem. 2005 Nov 18;280(46):38471-7. doi: 10.1074/jbc.M507013200. Epub 2005 Sep 12. PubMed PMC
  2. 2.
    Baburin I, Beyl S, Hering S. Automated fast perfusion of Xenopus oocytes for drug screening.
    Pflugers Arch. 2006 Oct;453(1):117-23. doi: 10.1007/s00424-006-0125-y. Epub 2006 Sep 5. PubMed PMC
  3. 3.
    Beyl S, Timin EN, Hohaus A, Stary A, Kudrnac M, Guy RH, Hering S. Probing the architecture of an L-type calcium channel with a charged phenylalkylamine: evidence for a widely open pore and drug trapping.
    J Biol Chem. 2007 Feb 9;282(6):3864-70. doi: 10.1074/jbc.M609153200. Epub 2006 Nov 30. PubMed PMC
  4. 4.
    Hering S, Beyl S, Stary A, Kudrnac M, Hohaus A, Guy HR, Timin E. Pore stability and gating in voltage-activated calcium channels.
    Channels (Austin). 2008 Mar-Apr;2(2):61-9. doi: 10.4161/chan.2.2.5999. Epub 2008 Mar 14. PubMed PMC
  5. 5.
    Stary A, Kudrnac M, Beyl S, Hohaus A, Timin EN, Wolschann P, Guy HR, Hering S. Molecular dynamics and mutational analysis of a channelopathy mutation in the IIS6 helix of Ca V 1.2.
    Channels (Austin). 2008 May-Jun;2(3):216-23. doi: 10.4161/chan.2.3.6160. Epub 2008 May 18. PubMed PMC
  6. 6.
    Kudrnac M, Beyl S, Hohaus A, Stary A, Peterbauer T, Timin E, Hering S. Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2.
    J Biol Chem. 2009 May 1;284(18):12276-84. doi: 10.1074/jbc.M808402200. Epub 2009 Mar 5. PubMed PMC
  7. 7.
    Beyl S, Kügler P, Kudrnac M, Hohaus A, Hering S, Timin E. Different pathways for activation and deactivation in CaV1.2: a minimal gating model.
    J Gen Physiol. 2009 Sep;134(3):231-41; S1-2. doi: 10.1085/jgp.200910272. Epub 2009 Aug 17. PubMed PMC
  8. 8.
    Beyl S, Depil K, Hohaus A, Stary-Weinzinger A, Timin E, Shabbir W, Kudrnac M, Hering S. Physicochemical properties of pore residues predict activation gating of Ca V1.2: a correlation mutation analysis.
    Pflugers Arch. 2011 Jan;461(1):53-63. doi: 10.1007/s00424-010-0885-2. Epub 2010 Oct 7. PubMed PMC
  9. 9.
    Shabbir W, Beyl S, Timin EN, Schellmann D, Erker T, Hohaus A, Hockerman GH, Hering S. Interaction of diltiazem with an intracellularly accessible binding site on Ca(V)1.2.
    Br J Pharmacol. 2011 Mar;162(5):1074-82. doi: 10.1111/j.1476-5381.2010.01091.x. PubMed PMC
  10. 10.
    Depil K, Beyl S, Stary-Weinzinger A, Hohaus A, Timin E, Hering S. Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 protein.
    J Biol Chem. 2011 Sep 9;286(36):31557-64. doi: 10.1074/jbc.M111.255273. Epub 2011 Jun 17. PubMed PMC
  11. 11.
    Beyl S, Depil K, Hohaus A, Stary-Weinzinger A, Linder T, Timin E, Hering S. Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model.
    Pflugers Arch. 2012 Oct;464(4):391-401. doi: 10.1007/s00424-012-1144-5. Epub 2012 Sep 2. PubMed PMC
  12. 12.
    Beyl S, Kügler P, Hohaus A, Depil K, Hering S, Timin E. Methods for quantification of pore-voltage sensor interaction in Ca(V)1.2.
    Pflugers Arch. 2014 Feb;466(2):265-74. doi: 10.1007/s00424-013-1319-8. Epub 2013 Jul 20. PubMed PMC
  13. 13.
    Beyl S, Hohaus A, Andranovits S, Timin E, Hering S. Upward movement of IS4 and IIIS4 is a rate-limiting stage in Cav1.2 activation.
    Pflugers Arch. 2016 Nov;468(11-12):1895-1907. doi: 10.1007/s00424-016-1895-5. Epub 2016 Oct 29. PubMed PMC
  14. 14.
    Saxena P, Hortigon-Vinagre MP, Beyl S, Baburin I, Andranovits S, Iqbal SM, Costa A, IJzerman AP, Kügler P, Timin E, Smith GL, Hering S. Correlation between human ether-a-go-go-related gene channel inhibition and action potential prolongation.
    Br J Pharmacol. 2017 Sep;174(18):3081-3093. doi: 10.1111/bph.13942. Epub 2017 Aug 11. PubMed PMC
  15. 15.
    Andranovits S, Beyl S, Hohaus A, Zangerl-Plessl EM, Timin E, Hering S. Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation.
    Pflugers Arch. 2017 Nov;469(11):1485-1493. doi: 10.1007/s00424-017-2038-3. Epub 2017 Aug 1. PubMed PMC
  16. 16.
    Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P, Linder T, Stary-Weinzinger A, van der Heyden MAG, Houtman M, Takanari H, Jonsson M, Beekman JHD, Hamburger M, Vos MA, Hering S. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo.
    Pharmacol Res. 2018 May;131:150-163. doi: 10.1016/j.phrs.2018.02.024. Epub 2018 Mar 15. PubMed
  17. 17.
    Hering S, Zangerl-Plessl EM, Beyl S, Hohaus A, Andranovits S, Timin EN. Calcium channel gating.
    Pflugers Arch. 2018 Sep;470(9):1291-1309. doi: 10.1007/s00424-018-2163-7. Epub 2018 Jun 27. PubMed PMC
  18. 18.
    Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham WB, Stary-Weinzinger A, Beyl S, Hering S, van den Berg DJ, de Lange ECM, Heitman LH, IJzerman AP, Vos MA, van der Heyden MAG. LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.
    Br J Pharmacol. 2019 Oct;176(19):3871-3885. doi: 10.1111/bph.14798. Epub 2019 Aug 30. PubMed PMC
  19. 19.
    Thurner M, Deutsch M, Janke K, Messner F, Kreutzer C, Beyl S, Couillard-Després S, Hering S, Troppmair J, Marksteiner R. Generation of myogenic progenitor cell-derived smooth muscle cells for sphincter regeneration.
    Stem Cell Res Ther. 2020 Jun 12;11(1):233. doi: 10.1186/s13287-020-01749-w. PubMed PMC
  20. 20.
    Baltov B, Beyl S, Baburin I, Reinhardt J, Szkokan P, Garifulina A, Timin E, Kraushaar U, Potterat O, Hamburger M, Kügler P, Hering S. Assay for evaluation of proarrhythmic effects of herbal products: Case study with 12 Evodia preparations.
    Toxicol Rep. 2023 Apr 26;10:589-599. doi: 10.1016/j.toxrep.2023.04.014. PubMed PMC

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