Targeting voltage-gated potassium channels for targeted immunomodulation
To ensure the safety and viability of potential drug candidates, we conduct thorough selectivity profiling by counter-screening against an extensive panel of other Kv channels.
Within the Kv1.X family of voltage-gated potassium channels, Kv1.3 has emerged as a highly specific and promising therapeutic target.
Kv1.3 channels are prominently expressed in immune cells, most notably in T-lymphocytes, and in particular, effector memory T cells (TEM). Kv1.3 channels play a vital physiological role: they regulate the resting membrane potential and provide the driving force necessary to support sustained calcium signaling during an active immune response. Kv1.3 is a high-value target for autoimmune diseases, metabolic disorders and cancer.
ChanPharm offers robust high-throughput screening studies on Kv1.3 utilizing automated patch clamp systems. To ensure the safety and viability of potential drug candidates, we perform deep selectivity profiling by counter-screening against an extensive panel of other Kv channels (Kv1.1, Kv1.2, and beyond).
A variety of peptides and small molecules have been identified or developed to block Kv1.3 channels:
SyncroPatch 384
Ion channel screening at scale.
Our high-throughput automated patch clamp platform is ideal for identifying Kv1.3 hits from large libraries and quickly counter-screening against closely related Kv1.X subtypes to determine compound selectivity.
Best suited for: Primary screening, hit confirmation, and high-throughput off-target profiling.
NANION TECHNOLOGIES HIGH THROUGHPUT
Patchliner
High-quality functional profiling with automation.
Provides medium-throughput automated patch clamp recordings with exceptional gigaseal quality, enabling nuanced pharmacological characterization of Kv1.3 blockers.
Best suited for: Secondary screening, lead optimization, and detailed selectivity studies.
NANION TECHNOLOGIES MEDIUM THROUGHPUT
Manual Patch Clamp
Gold-standard ion channel electrophysiology.
Manual patch clamp delivers unmatched experimental control, perfect for elucidating the precise binding kinetics and mechanism of action of novel Kv1.3 immunomodulators.
Best suited for: Detailed kinetics, complex protocols, and mechanism-of-action studies.
CONVENTIONAL SYSTEMS GOLD STANDARD