Targeting ionotropic glutamate receptors for neuroprotection and excitatory neurotransmission
The NMDA receptor (specifically the GluN1/GluN2B subtype) is an ionotropic receptor that mediates excitatory neurotransmission in the central nervous system (CNS). These ion channels play a central role in synaptic plasticity, learning, and memory. They are also the primary drivers of excitotoxicity—a form of severe tissue damage caused by excessive neuronal stimulation. The GluN1/GluN2B subtype is highly abundant in the developing brain during late embryonic and early postnatal stages, and remains specifically localized in adult brain regions such as the cortex, hippocampus, and amygdala. GluN2B-selective antagonists are under development to provide neuroprotection and treat various CNS disorders such as Parkinson's disease and Alzheimer's disease, stroke and ischemia, major depression (antidepressant effects) and anxiety disorders.
Because overactivation leads to excitotoxic neuronal death, GluN2B-selective antagonists are under development to provide neuroprotection and treat various CNS disorders such as neurodegenerative diseases, stroke and ischemia and psychiatric and seizure disorders.
ChanPharm offers comprehensive high-throughput screening studies specifically tailored for NMDA receptors. We employ both automated patch clamp systems and conventional manual patch clamp techniques to deliver robust pharmacological data.
The industry has developed several potent GluN2B-selective antagonists to probe receptor function and for clinical application (e.g., as novel anesthetics or fast-acting antidepressants):
SyncroPatch 384
Ligand-gated channel screening at scale.
Our high-throughput automated patch clamp platform is fully equipped for rapid fluidics and compound application, making it ideal for the large-scale screening of NMDA receptor antagonists.
Best suited for: Primary screening, hit confirmation, and robust concentration-response profiling.
NANION TECHNOLOGIES HIGH THROUGHPUT
Patchliner
High-quality functional profiling with automation.
Provides medium-throughput automated patch clamp recordings with rapid and precise compound application, essential for analyzing complex ligand-gated receptors.
Best suited for: Secondary screening, selectivity studies, and detailed pharmacological profiling.
NANION TECHNOLOGIES MEDIUM THROUGHPUT
Manual Patch Clamp
Gold-standard ion channel electrophysiology.
Manual patch clamp paired with ultra-fast perfusion systems provides unmatched experimental control for studying ligand binding and receptor kinetics.
Best suited for: Detailed receptor kinetics, complex pharmacological protocols, and validation of screening results.
CONVENTIONAL SYSTEMS GOLD STANDARD