Ion Channel Screening
We provide high-quality data for early compound screening and lead optimization making use of our automated patch-clamp platforms. Our assays account for special features of the respective ion channel targets and, at the same time, address specific demands of our customers. Close contact with our customers is the secret to ChanPharm's success.
Screening of large substance libraries is performed using automated high throughput automated patch-clamp platforms (SyncroPatch and Patchliner). Upon request studies on the mechanism of action of potential lead structures or drug candidates can be performed with manual patch-clamp. Depending on project requirements, ion channel screening includes selectivity profiling, cardiac safety assessment and neurotoxicity evaluation at any stage.
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Cardiac Safety Studies
Advanced cardiac safety testing using human iPSC-derived cardiomyocytes and CiPA-compliant assays. Our comprehensive assessment includes hERG screening, multi-channel cardiac panels, and in silico modeling to predict pro-arrhythmic risk and support regulatory submissions.
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Neurotoxicity Services
- Manual patch-clamp studies on primary neurons
- Manual patch-clamp studies on stem cell derived human neurons
- MEA studies on primary neuronal cells and stem cell derived human neurons
