Functional ion channel assays

ChanPharm offers a large collection of functional ion channel assays for selectivity profiling. Our functional assays utilize automated electrophysiology platforms and manual patch clamp

Safety assessment studies on ion channels

ChanPharm’s safety assessment panel covers key ion channels and enables identification of adverse drug reactions. Profiling against a broad panel of these off-targets at an early stage of drug development supports lead generation, lead optimization and selection of a drug candidate.

Customized cell line generation

Stable cell lines expressing recombinant ion channels are commonly used in drug discovery and safety assessment

Virtual drug screening and drug discovery services

Pharmacophore-based in-silico screening is an efficient and well established method for filtering large virtual compound libraries

We are ChanPharm

Your contract research organisation (CRO) offering compound screening and selectivity profiling for a broad range of ion channels.

We are proud to contribute to the field of ion channel research for more than 30 years now. Our scientists specialise in developing, optimising and validating our screening services using cutting-edge technologies, electrophysiology and fluorescence-based platforms. We are experts in developing ion channel assays that always address the individual demands of our clients on point.

Ion Channel Screening Services / Drug Discovery

ChanPharm provides high-quality ion channel screening services to its clients. Our research platforms include: automated patch clamp (Synchropatch and Patchliner), manual patch clamp studies and imaging. ChanPharm’s service includes screening of large compound libraries as well as studies on the mechanism of drug action of potential lead candidates.

Cardiac Safety Services

ChanPharm’s cardiac safety studies are based on assessment of drug effects on human induced pluripotent stem cell-derived (iPSC) cardiomyocytes, electrophysiological studies on cardiac ionic channels expressed in mammalian cell lines and in silico reconstruction of drug effects on human ventricular action potentials.

Neurotoxicity Services

ChanPharm has growing experience using human iPSC-derived neurons in our drug discovery programs and neurotoxicity assays. We use commercially available iPSC in studies with planar patch clamp platforms and MEAs (Garifulina et al. 2022).

Structure Activity Studies

ChanPharm supports structure-activity studies for our clients. Structural changes proposed by our clients are introduced into ion channels and resulting mutants are examined with regard to altered drug sensitivity.