Stem Cell Models
What We Offer
Our stem cell services provide human-relevant, mechanistic data to guide early-stage research and lead optimization.
- Modeling human biology and disease in vitro
- Evaluating drug effects on cellular physiology and function
- Supporting toxicity and safety assessment
- Enabling mechanistic and translational research
Stem Cell Models & Experimental Formats
Cellular Models
- Human iPSC-derived cardiomyocytes, neurons, and other cell types
- Co-culture systems for tissue-level interactions
Experimental Formats
- Single cells
- Monolayers
- 2D networks
- 3D spheroids / microtissues / organoids
These multi-scale formats allow translation from cellular to tissue-level function.
Methods & Data
- Electrophysiology: action potentials, ion channel currents, excitability
- Functional Imaging: calcium transients, voltage dynamics
- Contractility & Mechanical Function (for cardiomyocytes)
- Network activity & synchrony (neurons or cardiac tissues)
Technologies
Our stem cell studies are supported by industry-standard platforms for electrophysiology, imaging, and 3D tissue modeling.
SyncroPatch 384 / Patchliner (Nanion)
Automated patch clamp for iPSC-derived cells.
The SyncroPatch 384 and Patchliner enable high-quality electrophysiological recordings from fragile iPSC-derived cardiomyocytes and neurons, supporting both high-throughput screening and detailed characterization of ion channel activity.
Best suited for: Ion channel pharmacology, action potential profiling, drug safety screening
NANION TECHNOLOGIES HIGH THROUGHPUT
MEA Systems (Multi Channel Systems)
Network-level electrophysiology.
Microelectrode Array (MEA) technology records extracellular field potentials from iPSC-derived cardiomyocyte or neuronal networks, capturing spontaneous activity, drug-induced changes in beat rate, and arrhythmia-like events in a physiological context.
Best suited for: Network activity analysis, cardiotoxicity / neurotoxicity assessment, chronic drug exposure
MCS PHYSIOLOGICAL RELEVANCE
High-Speed sCMOS Imaging (Kinetix)
High-speed functional imaging.
The Kinetix sCMOS camera enables rapid imaging of calcium transients and voltage dynamics in large cell populations with exceptional temporal resolution, supporting phenotypic analysis across 2D monolayers and 3D tissues.
Best suited for: Calcium handling, voltage dynamics, high-content phenotypic profiling
PHOTOMETRICS HIGH SPEED
3D Microtissue Platforms
Tissue-level modeling.
3D spheroid and organoid platforms allow iPSC-derived cells to self-organize into architecturally relevant microtissues, enabling studies that better recapitulate in vivo physiology compared to standard 2D cultures.
Best suited for: Disease modeling, toxicity studies in complex tissue environments, translational research
3D MODELS ORGANOIDS